If you enabled Realtek onboard audio using the CloverALC110 script, no changes will be necessary. If you're using a NVIDIA 'Maxwell' GeForce GTX 750, 750 Ti, 950, 960, 970, 980, 980 Ti, or TITAN X graphics card, install the 10.11.1 update, reboot with nv_disable=1 boot argument, then install the new drivers and reboot normally.
Initial support for Intel's 6th Generation Skylake CPUs and 100 Series Chipsets.Building a CustoMac Hackintosh: Buyer's Guide